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      A POWERFUL RESEARCH AND
      DEVELOPMENT ENGINE

      Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

      • Phase 1 trials

        Phase 1 Trials

        CEMIPLIMAB*

        PD-1 Antibody
        Cancer

        REGN3767

        LAG-3 Antibody
        Cancer

        REGN1979

        CD20xCD3 Antibody
        Cancer

        REGN4018*

        MUC16xCD3 Antibody
        Cancer

        REGN4659

        CTLA4 Antibody
        Cancer

        REGN5458*

        BCMAxCD3 Antibody
        Cancer

        REGN3048-3051

        Middle East Respiratory Coronavirus Antibody
        MERS-CoV infection

        REGN4461

        LEPR Antibody
        Lipodystrophy and obesity

        REGN5713-5714-5715

        Betv1 Antibody
        Birch Allergy
      • Phase 2 trials

        Phase 2 Trials

        CEMIPLIMAB*

        PD-1 Antibody
        Basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC)
        REGN1979
        CD20xCD3 Antibody
        Relapsed / refractory follicular lymphoma

        DUPILUMAB*

        IL-4R Antibody
        Grass allergy, peanut allergy

        SARILUMAB*

        IL-6R Antibody
        Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis

        REGN1908-1909

        Fel d 1 Antibody
        Cat allergy

        REGN3500*

        IL-33 Antibody
        Asthma, chronic obstructive pulmonary disease (COPD), atopic dermatitis

        REGN5069

        GFRα3 Antibody
        Osteoarthritis knee pain

        GARETOSMAB

        Activin A Antibody
        Fibrodysplasia Ossificans Progressiva (FOP)

        EVINACUMAB

        ANGPTL-3 Antibody
        Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia

        POZELIMAB

        C5 Antibody
        Paroxysmal nocturnal hemoglobinuria
      • Phase 3 trials

        Phase 3 Trials

        AFLIBERCEPT
        VEGF-Trap
        Non-proliferative diabetic retinopathy (NPDR) without DME

        ALIROCUMAB*

        PCSK9 Antibody
        Homozygous familial hypercholesterolemia (HoFH) in adults and pediatrics, heterozygous familial hypercholesterolemia in pediatrics

        CEMIPLIMAB*

        PD-1 Antibody
        Non-small cell lung cancer, cervical cancer

        REGN-EB3

        Ebola Virus Antibody
        Ebola virus infection

        DUPILUMAB*

        IL-4R Antibody
        Atopic dermatitis in pediatrics, asthma in pediatric, eosinophilic esophagitis, COPD

        SARILUMAB*

        IL-6R Antibody
        Polymyalgia rheumatica, giant cell arteritis

        EVINACUMAB

        ANGPTL-3 Antibody
        Homozygous familial hypercholesterolemia (HoFH)

        FASINUMAB?

        NGF Antibody
        Chronic pain from osteoarthritis of the knee or hip

      Trials Footnotes

      * in collaboration with Sanofi

      ? in collaboration with Teva and Mitsubishi Tanabe

      This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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